Tenvir-EM Vs Truvada PrEP Pills

Several clinical trials have shown that prophylaxis using tenofovir disoproxil fumarate and emtricitabine significantly reduces the risk of getting infected with the virus. Since the emergence of PrEP, the rate at which HIV spreads has been reduced drastically. Let’s compare Truvada and its generic Tenvir-EM to choose a really effective drug for PrEP.

The effectiveness level of PrEP is over 90%. Truvada is the medicine used for the procedure. Up unitl now, it is the only drug besides the generic versions that has been approved for PrEP by the Food and Drug Administration (FDA). However, Tenvir-EM has been approved by the FDA as a generic version of Truvada.

Generic drugs are those made after a brand name drug. They are formulated with the same active constituents so that they offer the same strength, dosage, routes of administration, risks and negative aftereffects as the original drug. In most cases, the generic versions of drugs differ from the original version only in name and packaging.

Generally, when new drugs are discovered, patents are secured to permit only the pioneering company to produce the drug for 10-20 years. At the expiration of the patent, other pharmaceuticals can then use the formula, but with a different name. The generic versions of drugs are always way cheaper in price compared to the brand drug, even though they are exactly the same in terms of effectiveness.

Tenvir-EM is one of the generic equivalents of Truvada. It has the same composition and produces the same effect. Similar in terms of the vital constituent make-up and functionality, Tenvir-EM is a cheaper approach to the prophylaxis strategy.

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⭐Features of Tenvir-EM Vs Truvada

Tenvir-EM pills are blue in color, film-coated with a capsule shape, and plain on both sides (having no scoreline – as the pills are not meant to be divided). Each pill contains 300 milligrams and 200 milligrams of tenofovir DF (disoproxil fumarate) and emtricitabine respectively. Tenvir-EM pills can be taken with or without food, but must be taken with water.

Based on its make-up (tenofovir DF and emtricitabine in appropriate amounts), Tenvir-EM can be used in the control and management of HIV in infected individuals, and for prevention in non-infected individuals. For use in the prophylaxis strategy, the tablets can be taken alone, however, for the treatment of HIV, they need to be combined with at least one or more antiretrovirals to be effective at managing the virus.

Truvada is available in tablet form. Each tablet also contains tenofovir and emtricitabine in the ratio of 300 milligrams to 200 milligrams, as its active ingredients. However, Truvada is also available in a number of other active ingredient concentrations, such as 150 mg/100 mg, 200 mg/133 mg, 167 mg/250 mg of emtricitabine and TDF (tenofovir disoproxil fumarate), respectively [1]. The actual strength of Truvada to be taken is dependent on factors such as the liver and kidney function of the patient as well as other medical conditions.

💊Are These Pills Equally Safe?

Yes, Tenvir-EM is equally safe.

When it comes to decreasing the risks associated with HIV infection in non-infected persons, Truvada is highly effective. It is also effective in controlling and managing the virus in infected individuals, and approved by the FDA. Before the FDA approves a drug for use, a series of tests (clinical trials) must be carried out over time to ensure that its benefits far outweigh its risks. The fact that Truvada is approved shows that it is safe for use. However, the drug may cause little negative aftereffects like nausea and headaches, but they often disappear within a short while [2].

Tenvir-EM, on the other hand, is formulated with exactly the same ingredients as Truvada and meets the same standards. Thus, it is equally safe for use. Both Tenvir-EM and Truvada have interwoven benefits and side effects, as well as contraindications.

In a nutshell, both drugs have equal levels of safety as they have the same make-up and pharmacological effects.

🔍Does Tenvir-EM Work Same As Truvada?

The effectiveness of Tenvir-EM is the same as Truvada. It is simply a generic alternative to Truvada. It has the same usage, dosage, side effects, route of administration, risks and strengths as Truvada. Both medicines are approved for use as PrEP, and to treat HIV infection when taken together with other antiretroviral medicines.

Just Like Truvada, Tenvir-EM works by interfering with reverse transcriptase (an enzyme which HIV-infected cells within the body use to multiply), by way of reducing its activity. When the activity of this enzyme is impeded, the virus stops replicating and the viral load begins to drop. If the patient continues to use this drug correctly and doesn’t miss a dose, the viral load will reduce to an extent that the virus becomes undetectable. This method of action only applies when Tavin-EM is used in combination therapy to manage or control HIV in people who are HIV-positive.

When used as PrEP, Tenvir-EM prevents HIV from getting to infect the cells and moving on to replicate throughout the individual’s body. It does this by forming a shell of protective molecules around the cells.

As long as the user continues to follow the prescription, the protective molecules remain intact, making it 92%- 99% unlikely for the person to get infected. However, if doses are skipped, the risk of contracting the virus rises again. Again, this is the very same way Truvada works when used for PrEP.

⚖Are There Any Differences in Dosage?

At this moment, not really.

While the only guaranteed dose for both medicines is the once-daily schedule where a single tablet of either drug is taken daily, new findings show that a new dosage schedule might be effective. This potential schedule is termed “on-demand” dosing.

On-demand dosing involves users taking two Truvada pills between two (2) and twenty-four (24) hours before sexual activity; one tablet a day after sex and another tablet 48 hours after sex. Research carried out on this method showed that people who followed “on-demand” dosing for PrEP were likely to attain the same level of protection as people who followed the once-daily schedule.

However, the once-daily protocol is the only dosing scheme that is FDA-approved for PrEP. So, technically, it will be right to say that there is no difference in dosage between Truvada and Tenvir-EM.

🤧Side Effects of Tenvir-EM & Truvada

Just like other medicines, Truvada & Tenvir-EM for PrEP has the potential to cause side effects in users. However, they are not life-threatening, as stated earlier, the potential adverse effects related to the intake of both meds are interwoven. The adverse effects of Truvada and Tenvir-EM are common. They include:

• vomiting;
• headaches;
• dizziness;
• nausea;
• indigestion;
• mood changes;
• rashes;
• abdominal pain.

Patients taking either Tenvir-EM or Truvada may or may not experience any of the above-listed side effects. Moreover, most cases of users experiencing side effects have been linked to incorrect usage of the drug. In a few cases, the cause of discomfort experienced by certain users relates to the body chemistry of the individual.

However, side effects only last for a few days, vanishing after the body becomes accustomed to the new drug.

🔁Tenvir-EM Vs Truvada: Interaction with Other Drugs

A drug that interacts with the individual components of Tenvir-EM and Truvada (tenofovir and emtricitabine) will also interact with the combined form. A drug that interacts with Truvada will also interact with Tenvir-EM, since their constituent ingredients are the same.

Some interactions can be lethal and in such cases, the drug usage is discontinued. Below are some drugs that interact with Truvada for PrEP, which interact with Tenvir-EM as well [3].

• NRTIs (nucleoside reverse transcriptase inhibitors): an example of a drug that belongs to this class of drugs is didanosine. Didanosine sometimes interacts with tenofovir DF, and this could lead to an adverse reaction. A patient on didanosine and Tenvir-EM or Truvada therapy is usually monitored for an adverse reaction. In the event that there is a reaction, didanosine is discontinued;
• HIV protease inhibitors: atazanavir, lopinavir/ritonavir, and darunavir/ritonavir belong to the class of protease inhibitors. The administration of Tenvir-EM & Truvada should be halted in patients who experience side effects resulting from the concomitant usage of the drugs;
• hepatitis C antiretroviral agents: drugs that fall into this class include sofosbuvir/velpatasvir and sofosbuvir/vixilaprevir, ledipasvir/sofosbuvir. A side effect can occur when drugs containing this agent is used alongside Truvada. The tenofovir DF content in Truvada is associated with the adverse effect due to hepatitis C antiretroviral drugs.

There are several other drugs that Tenvir-EM, as well as Truvada, can interact with, some with minimal side effects, and others with more serious consequences. It is always advisable to seek the advice of a doctor or healthcare practitioner before using other medicines.

🏭Manufacturers of Truvada and Tenvir-EM

Gilead Sciences Inc. is the biopharmaceutical industry behind the development of Truvada. It is a company based in Foster City, California. The company was created in 1987 and works majorly to develop medications for diseases that currently do not have treatment options.

Tenvir-EM was produced by a company based in India called Cipla Limited that was founded in 1935. The company focuses on developing medicines to treat arthritis, diabetes, respiratory and cardiovascular disease, depression, and other medical conditions. They manufacture the generic alternative to Truvada.

💵Tenvir-EM Vs Truvada Prices

In the United States, Truvada is sold at an average price of $1,500 for 30 tablets. On the other hand, Tenvir-EM goes for about $80 for 30 tablets. Though the prices are a little on the high side, they may vary based on location, or the store selling the medication. Certain online pharmacies put out drugs at affordable prices and also offer great deals to users.

While Truvada can be purchased from various pharmacies worldwide, its counterpart, Tenvir-EM, the generic form of Truvada, can only be bought from online pharmacies until the patent covering Truvada expires. Generic PrEP is more accessible and affordable as well.

📊Facts & Statistics of Tenvir-EM Vs Truvada

It has been established that Tenir-EM and Truvada share a lot of similarities and also differ slightly in some areas (price and packaging for example). However, for quick reference, here are some basic facts and statistics of both drugs:

• the FDA gave approval for Truvada to be used for PrEP in the year 2012;
• both Tenvir-EM and Truvada reduce the risk of non-infected individuals contracting the virus by over 90%. However, for this level of protection to be attained, the prescription must be followed strictly, i.e. the pill is taken 7 days a week, consistently;
• on estimate, within the last four (4) years, over 79, 000 people worldwide have relied on Truvada for PrEP;
• it is quite difficult to determine the number of Tenvir-EM users worldwide as the medication is only sold online at the moment.

Through this text – Tenvir-EM Vs Truvada, it can be seen that the major difference between both drugs is their availability, packaging, company producing them and the price they are sold at. A majority of persons using PrEP go for the alternative (generic version) over the main drug (Truvada), due to its exorbitant price. About 92% – 99% protection against HIV is assured with either of these drugs. However, they must be taken as prescribed.

More information regarding Tenvir-EM, Truvada and other generic medicines that may be used for pre-exposure prophylaxis strategy can be found on HIVPrEP. Questions and answers, as well as tips on HIV risks and preventive strategies, can also be found on this informative site.

📚References

1. Truvada|dosage, side effects. AIDSinfo. November 22, 2012
2. Pre-Exposure Prophylaxis. HIV.gov. Revised on May 21, 2018
3. Guide: Does PrEP interact with any other medications. HIV i-Base. Revised 18, March 2019.