Coadministering these drugs doesn’t result in significant interactions, and they can be used together without dose adjustment. Interactions might occur, and it’s necessary to always consult with a medical specialist to prescribe the right drug combinations that are effective and beneficial to your health.
Tivicay belongs to the INSTI group of drugs, which means it blocks an integrase enzyme, thus preventing the virus from replicating. It’s a highly effective antiretroviral medicine having dolutegravir as an active ingredient. Tivicay is used as a part of a combination therapy together with other ARV meds to treat HIV/AIDS [1].
Prezista belongs to the group of protease inhibitors. It is a highly effective medicine prescribed to fight HIV/AIDS. It has an active substance darunavir that plays a key role in suppressing the virus and building the CD4+ cell count. Prezista is used in combination with other ARV meds to effectively combat the virus and build a stronger immune function [2].
From clinical studies, there is no dosage adjustment needed when darunavir is co-administered with Tivicay (dolutegravir).
A combination of Tivicay and darunavir decreases dolutegravir AUC, Cmax, and C24 by 22%, 11%, and 38% respectively. The major reason for this decrease is due to induction of UGT1A1 and CYP3A enzymes.
These test results show that the interaction is insignificant and doesn’t cause harm to the patient’s health. Note that a doctor’s prescription is very important when you need a drug combination regimen that fully works well without causing harm to your health [3].