Tivicay (Dolutegravir) + Norvir (Ritonavir)

Tivicay and Norvir can be coadministered without any problem. But do not combine these meds alone. It’s necessary to consult with a medical specialist to assess your health and prescribe you the right medication regimen.

Main Information About Tivicay

Tivicay is an approved anti-HIV medication potent for treating HIV. It’s used in combination with other ARV meds to fully prevent the virus from spreading and destroying the immune function. By suppressing the viral load, a patient can lead a stronger and healthier life even with the virus. Tivicay has dolutegravir as an active substance that belongs to the INSTI drug class [1].

What Is Norvir?

Norvir contains the active ingredient ritonavir. It is a highly potent medication, but it is not an antiretroviral activity that is most valued in it, but rather it’s used as a booster for another medicine along with other anti-HIV drugs to treat the HIV infection. Therefore, a small dose is usually used with other protease inhibitors to fully suppress the viral load in the patient’s body, boost the CD4+ cell count, and build a stronger immune function [2].

Dolutegravir and Ritonavir Stack: Can Interaction Occur?

There exist no clinically significant interaction when the two meds are coadministered. Clinical data depicts that dolutegravir does not affect the pharmacokinetics of Norvir (ritonavir), and no dosage adjustment is necessary if the two meds are to be coadministered [3]. It doesn’t mean that no interaction at all is possible, as minor drug interactions do not usually trigger harmful effects or require a change in therapy, so they are considered clinically irrelevant.

Therefore, such a combination is safe, but only the doctor can prescribe you both meds after a full health assessment.


  1. TIVICAY®. Viivhealthcare.com.
  2. NORVIR® (ritonavir). Norvir.com.
  3. Drug Interaction Report. Tivicay (dolutegravir) Vs Norvir (ritonavir). Drugs.com.
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