Isentress (Raltegravir) + Norvir (Ritonavir)

Isentress and Norvir can be used simultaneously with no negative interaction or side-effects. However, as in the case of any HIV medication, it is important to consult a doctor before usage.

Isentress: Uses and Dosage

Isentress is a popular antiretroviral medicine that is used in combination with certain other HIV meds for the treatment of HIV. In an average number of cases, this medication can also be used as a part of post-exposure prophylaxis (PEP) after prior exposure to the virus.

This medicine was given the official stamp of approval for medical use in the United States in 2007. Ever since then, its popularity as an effective treatment for HIV has skyrocketed.

The active component in Isentress is raltegravir. It belongs to a class of drugs commonly referred to as integrase inhibitors [1]. Thus, it works by targeting an HIV enzyme known as integrase. Isentress inhibits the actions of integrase and stops the replication of the virus in the body. Subsequently, the viral load drops over time until it becomes undetectable.

Norvir: Uses and Dosage

Norvir is yet another HIV medication that is used in combination with other related drugs for the treatment of HIV. Its active component is ritonavir that was patented in 1989. Despite this, it was not officially used for medical purposes until 1996. Currently, it is on the World Health Organisation’s list of essential medicines and as such is counted as a reliable and reputable antiretroviral medication.

Norvir is taken orally and at the same time with other HIV meds. The tablet form of this drug should be swallowed whole without crushing or breaking it [2]. It should be noted that this medication merely prevents the spread of HIV within the body and can’t be considered a cure.

Drugs Interaction: Isentress and Norvir

Isentress and Norvir do not interact with each other in a way that is harmful. Thus, they can be combined. The interactions have been found to differ based on the dose of both drugs being taken [3].

In a trial carried out on healthy subjects, upon the administration of a single 400 mg dose of raltegravir followed by the administration of a 100 mg-twice-daily-dose of ritonavir for 16 days, there was no significant change in the metabolism and excretion of the active substances of the drugs.

Whatever the case may be, consult a doctor to determine what dosage will best fit your needs providing the best treatment without causing any serious side effects.


  1. Raltegravir.
  2. Norvir Capsule.
  3. Minimal effects of ritonavir and efavirenz on the pharmacokinetics of raltegravir. Iwamoto M, Wenning LA, Petry AS, et al. Antimicrob Agents Chemother. 2008; 52(12):4338–4343. doi:10.1128/AAC.01543-07. Published 2008 October 6.
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